August 01, 2025

[Press Release] Human cytokine equipped with abiotic multinuclear metal center exhibits intrinsic and extrinsic functions

Designer enzyme

Designer enzyme
Structural equivalence is demonstrated through the comparison of a synthetic multinuclear metal complex (left) versus the designer enzyme in this report (right).
(CREDIT: Yasunori Okamoto USAGE RESTRICTIONS: Author permission required for redistribution.  LICENSE: Original content)

Release Summary

Japanese researchers have developed a human cytokine-based designer enzyme. Relying on their rational design workflow, they demonstrated that proteins can serve as ligands with the same precision as synthetic organic ligands. The resulting designer enzyme maintains its original biological functions while gaining new catalytic abilities.

For Details

Publication Information

  • Journal: Nature Communications
  • Title: A Cytokine-based Designer Enzyme with an Abiological Multinuclear Metal Center Exhibits Intrinsic and Extrinsic Catalysis
  • Authors: Akiko Ueno#, Fumiko Takida#, Tomoki Kita, Takuro Ishii, Tomoki Himiyama, Takuya Mabuchi, and Yasunori Okamoto
    #These authors contributed equally,Corresponding Author)
  • DOI: 10.1038/s41467-025-61909-5

Related links

PAGE TOP